Atr Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comAtr Polyclonal Antibody for Mouse(Mus musculus)

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Atr (Gene name),

Serine/threonine-protein kinase ATR (Protein name ), ATR_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Atr(Kiaa4069);

Protein name:

Serine/threonine-protein kinase ATR;

Alternative:

Ataxia telangiectasia and Rad3-related protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms an heterodimer with ATRIP. Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164 (By similarity). Interacts with TELO2 AND TTI1.

Function:

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates Ser-139 of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (By similarity). Essential for preventing the occurrence of DNA damage during early embryogenesis.

Subcellular Location:

Nucleus Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.

Protein Attributes:

Sequence length:

2635

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TGLPLSIEGH | VHYLIQEATD | ENLLCQMYLG | WTPYM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.212462

Pfam:

PF02259

String:

Q9JKK8

SMR:

Q9JKK8

Uniprot:

Q9JKK8

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ELISA Kit for Mouse Serine/threonine-protein kinase ATR

Cat.:

E15117m

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Packing:

96T

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ELISA Kit for Mouse Serine/threonine-protein kinase ATR

Cat.:

E15117h

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96T

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CLIA Kit for Mouse Serine/threonine-protein kinase ATR

Cat.:

U15117m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Serine/threonine-protein kinase ATR

Cat.:

U15117h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Serine/threonine-protein kinase ATR

Cat.:

P15117Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine/threonine-protein kinase ATR

Cat.:

P15117Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Serine/threonine-protein kinase ATR

Protein for Mouse Serine/threonine-protein kinase ATR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1134 AND 1578-2635
strain: C57BL/6J.
strain: NOD.
tissue: Brain.
tissue: Dendritic cell.
tissue: Egg.
tissue: Embryo.
tissue: Lung.
3.

"Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Kitamura H. , Nakagawa T. , Nagase T. , Ohara O. , Koga H.
DNA Res.11:127-135(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1684-2635
tissue: Embryonic intestine.
4.

"Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice."
de Klein A. , Muijtjens M. , van Os R. , Verhoeven Y. , Smit B. , Carr A.M. , Lehmann A.R. , Hoeijmakers J.H.J.
Curr. Biol.10:479-482(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2362-2635;FUNCTION
5.

"The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes."
Keegan K.S. , Holtzman D.A. , Plug A.W. , Christenson E.R. , Brainerd E.E. , Flaggs G. , Bentley N.J. , Taylor E.M. , Meyn M.S. , Moss S.B. , Carr A.M. , Ashley T. , Hoekstra M.F.
Genes Dev.10:2423-2437(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"ATR disruption leads to chromosomal fragmentation and early embryonic lethality."
Brown E.J. , Baltimore D.
Genes Dev.14:397-402(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance."
Brown E.J. , Baltimore D.
Genes Dev.17:615-628(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."
Takai H. , Xie Y. , de Lange T. , Pavletich N.P.
Genes Dev.24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATRIP
9.

"HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity."
Kogo H. , Tsutsumi M. , Inagaki H. , Ohye T. , Kiyonari H. , Kurahashi H.
Genes Cells17:897-912(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
10.

"Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms."
Wojtasz L. , Cloutier J.M. , Baumann M. , Daniel K. , Varga J. , Fu J. , Anastassiadis K. , Stewart A.F. , Remenyi A. , Turner J.M. , Toth A.
Genes Dev.26:958-973(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION

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